Resource Type

Journal Article 118

Conference Information 1

Conference Videos 1

Year

2023 11

2022 12

2021 12

2020 7

2019 13

2018 9

2017 6

2016 6

2015 4

2014 8

2013 2

2012 4

2011 2

2010 6

2009 3

2008 5

2007 8

2006 1

2003 1

open ︾

Keywords

DNA 9

assembly 7

DNA damage 6

DNA methylation 6

self-assembly 6

1 2

Community assembly 2

DNA assembly 2

DNA repair 2

MoS2 2

acute myeloid leukemia 2

organogelator 2

2 1

3 1

3-triazole derivatives 1

3D measurement 1

4-oxadiazoles 1

Lymnea luteola 1

RUNX1 1

open ︾

Search scope:

排序： Display mode:

Developing a Transformation-Independent and Unbiased qPCR Assay to Rapidly Evaluate the Determinants of DNAAssembly Efficiency Article

Xiaoyan Ma, Xinxin Liang, Yi-Xin Huo

Engineering 2019, Volume 5, Issue 4,   Pages 803-810 doi: 10.1016/j.eng.2019.06.002

Abstract: moving in the direction of larger and more sophisticated design, which depends heavily on the efficient assemblyConventional evaluation of the DNA assembly efficiency (AE) requires transformation, and the whole process, and Gibson assembly for the assembly of two or more DNA pieces; the results correlated significantlyThe method was then employed to investigate the effects of terminal secondary structures on DNA assemblyThe qPCR-based approach presented here should facilitate the development of DNA assembly techniques and

Keywords： Assembly efficiency     DNA assembly     qPCR     Secondary structure     Transformation    

HTML PDF Collect

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 117-125 doi: 10.1007/s11705-016-1601-3

Abstract: Single-gene overexpression and DNA assembly-directed multigene overexpression affect the production of

Keywords： resveratrol     aromatic amino acid     DNA assembly     metabolic engineering     gene overexpression    

HTML PDF Collect

Assembly of biosynthetic pathways in

Lidan Ye,Xiaomei Lv,Hongwei Yu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 126-132 doi: 10.1007/s11705-016-1597-8

Abstract: A robust and versatile tool for multigene pathway assembly is a key to the biosynthesis of high-valueelement replacement, shuttle plasmid, auxotrophic marker independence, GAL regulation, and decentralized assembly

Keywords： pathway assembly     toolbox     reiterative recombination     S. cerevisiae     biosynthesis    

HTML PDF Collect

A novel task-oriented framework for dual-arm robotic assembly task

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 528-545 doi: 10.1007/s11465-021-0638-2

Abstract: In industrial manufacturing, the deployment of dual-arm robots in assembly tasks has become a trend.planning with visual perception to facilitate robot deployment from perception to execution and finish assemblyThe assembly task and manipulation sequences can be obtained by analyzing and reasoning the state transitionNext, the corresponding assembly manipulation can be generated and parameterized according to the differences

Keywords： dual-arm assembly     AI reasoning     intelligent system     task-oriented motion planning     visual perception    

HTML PDF Collect

Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

Ullah SAIF,Zailin GUAN,Baoxi WANG,Jahanzeb MIRZA

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 3,   Pages 257-264 doi: 10.1007/s11465-014-0294-x

Abstract: an application of the proposed method on a simple problem of multi objective optimization of simple assembly

Keywords： Pareto     lexicographic α-robust     assembly line balancing    

HTML PDF Collect

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System Article

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Engineering 2023, Volume 29, Issue 10,   Pages 130-136 doi: 10.1016/j.eng.2022.05.023

Abstract: However, the current data-writing process of DNA data storage via DNA synthesis suffers from high costsHere, we developed a DNA movable-type storage system that can utilize DNA fragments pre-produced by cellIn this system, these pre-generated DNA fragments, referred to herein as "DNA movable types,"The process of data writing is achieved by the rapid assembly of these DNA movable types, thereby avoidingThrough its repetitive usage and biological assembly of DNA movable-type fragments, this system exhibits

Keywords： 合成生物学     DNA信息存储     DNA活字存储系统     经济性DNA数据存储    

HTML PDF Collect

Assembly design system based on engineering connection

Wensheng YIN

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 4,   Pages 423-432 doi: 10.1007/s11465-016-0382-1

Abstract:

An assembly design system is an important part of computer-aided design systems, which are importantThe traditional assembly design system does not record the connection information of production on theAn assembly design model based on the relationship of engineering connection is presented.The model is an And/Or graph and has the ability to record all assembly schemes.Finally, VC++6.0 is used to develop a prototype system called Connect-based Assembly Planning (CAP).

Keywords： product design     assembly design     engineering connection     assembly sequence planning    

HTML PDF Collect

Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 509-515 doi: 10.1007/s11705-017-1613-7

Abstract: Enzyme-instructed self-assembly (EISA) offers a facile approach to explore the supramolecular assemblies

Keywords： enzyme-instructed self-assembly     phosphoserine     phosphatase     supramolecular hydrogel    

HTML PDF Collect

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 156-164 doi: 10.1007/s11684-012-0197-3

Abstract: ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNAThe present review will focus on recent progress on the role of PARP1 in the DNA damage response andresistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA

Keywords： PARP1     synthetic lethality     PARP inhibitor     DNA repair     cancer     NHEJ    

HTML PDF Collect

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 179-187 doi: 10.1007/s11705-009-0268-4

Abstract: our understanding of the mechanism of activation of ATM and its signaling pathways, explore whether DNA

Keywords： ataxia-telangiectasia mutated (ATM)     cell cycle checkpoint     DNA damage     signalling transduction    

HTML PDF Collect

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA doubleThus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repairedregulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA

Keywords： class switch recombination     somatic hypermutation     activation-induced deaminase     DNA repair     genomic instability    

HTML PDF Collect

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 133-139 doi: 10.1007/s11705-018-1737-4

Abstract: In , the global transcriptional regulatory factor CodY can interact with the promoter DNA to regulateIn order to study the mechanism of interaction between CodY and its target DNA, molecular docking andARG218, SER219, ASN223, LYS242 and GLY243, among which SER186, ARG218 and LYS242 play a vital role in DNA

Keywords： CodY     DNA     molecular docking     molecular dynamics    

HTML PDF Collect

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancerIn this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicinewere summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylationFurthermore, prospective applications of DNA methylation to environmental pollution detection and cancer

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

HTML PDF Collect

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 185-190 doi: 10.15302/J-FASE-2014035

Abstract: DNA damage is one of the most common threats to meiotic cells.Here, we reviewed exogenous factors which could induce DNA damage.Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic developmentComplex DNA damage, double-strand breaks, represents a more difficult repair process and involves variousUnderstanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for

Keywords： DNA damage     double-strand breaks (DSBs)     oocyte     embryo    

HTML PDF Collect

Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures Review

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Engineering 2023, Volume 24, Issue 5,   Pages 277-292 doi: 10.1016/j.eng.2022.10.009

Abstract:

DNA is considered to be not only a carrier of the genetic information of life but also a highly programmableDifferent DNA structures are related to their biological and chemical functions.However, the bulk assay ignores the heterogeneity of DNA structures in solution.(ss/dsDNA), DNA higher-order structures, and DNA nanostructures.methods to understand the biophysical properties of DNA and other bio-matter and soft matter.

Keywords： Single-molecule methods     DNA structure     Mechanical properties     Conformational transitions    

HTML PDF Collect

Title Author Date Type Operation

Developing a Transformation-Independent and Unbiased qPCR Assay to Rapidly Evaluate the Determinants of DNAAssembly Efficiency

Xiaoyan Ma, Xinxin Liang, Yi-Xin Huo

Journal Article

Profiling influences of gene overexpression on heterologous resveratrol production in

Duo Liu,Bingzhi Li,Hong Liu,Xuejiao Guo,Yingjin Yuan

Journal Article

Assembly of biosynthetic pathways in

Lidan Ye,Xiaomei Lv,Hongwei Yu

Journal Article

A novel task-oriented framework for dual-arm robotic assembly task

Journal Article

Pareto lexicographic α-robust approach and its application in robust multi objective assembly line balancing

Ullah SAIF,Zailin GUAN,Baoxi WANG,Jahanzeb MIRZA

Journal Article

Engineering DNA Materials for Sustainable Data Storage Using a DNA Movable-Type System

Zi-Yi Gong, Li-Fu Song, Guang-Sheng Pei, Yu-Fei Dong, Bing-Zhi Li, Ying-Jin Yuan

Journal Article

Assembly design system based on engineering connection

Wensheng YIN

Journal Article

Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels

Jie Zhou, Xuewen Du, Jiaqing Wang, Natsuko Yamagata, Bing Xu

Journal Article

The role of PARP1 in the DNA damage response and its application in tumor therapy

Zhifeng Wang, Fengli Wang, Tieshan Tang, Caixia Guo

Journal Article

Functional role of ATM in the cellular response to DNA damage

Ming LIU, Wenxiang HU

Journal Article

Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Journal Article

Molecular simulation of the interaction mechanism between CodY protein and DNA in

Linchen Yuan, Hao Wu, Yue Zhao, Xiaoyu Qin, Yanni Li

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Journal Article

Single-Molecule Methods for Characterizing Different DNA Higher-Order Structures

Yonglin Liu, Tianyuan Bian, Yan Liu, Zhimin Li, Yufeng Pei, Jie Song

Journal Article